Calculate dose-transition pathways for an EffTox study. Note that TODO TODO TODO

efftox_dtps_to_dataframe(dat, cohort_sizes, next_dose, ...)

Arguments

dat

An instance of efftox_params, a list of EffTox parameters. An example is yielded by efftox_parameters_demo.

cohort_sizes

vector of future cohort sizes, i.e. positive integers. E.g. To calculate paths for the the next cohort of two followed by another cohort of three, use cohort_sizes = c(2, 3).

next_dose

the dose-level to be given to the immediately next cohort.

...

extra params passed to rstan::sampling.

Value

dose pathways in a data.frame.

References

Brock K, Billingham L, Copland M, Siddique S, Sirovica M, Yap C. Implementing the EffTox dose-finding design in the Matchpoint trial. BMC Medical Research Methodology. 2017;17(1):112. doi:10.1186/s12874-017-0381-x

See also

Examples

# Calculate the paths for the first cohort of 3 in Thall et al 2014 example dat <- efftox_parameters_demo() if (FALSE) { dtps1 <- efftox_dtps_to_dataframe(dat = dat, cohort_sizes = c(3), next_dose = 1) } # To calculate future paths in a partially-observed trial dat <- efftox_parameters_demo() dat$doses = array(c(1,1,1)) dat$eff = array(c(0,0,0)) dat$tox = array(c(1,1,1)) dat$num_patients = 3 if (FALSE) { dtps2 <- efftox_dtps_to_dataframe(dat = dat, cohort_sizes = c(3), next_dose = 1) }