Continual Reassessment Method
Neuenschwander, Branson & Gsponer
Toxicity Probability Interval Design
Modified Toxicity Probability Interval Design
Bayesian Optimal Interval Design
Working with dose-paths
Simulating dose-escalation trials
Added Neuenschwander, Branson & Sponer’s method for phase I.
Added Ji et al.’s TPI & mTI methods for phase I.
Added Thall & Cook’s EffTox method for phase I/II.
Added Wages & Tait’s method for phase I/II.
Mainly small changes to comply with dplyr v1.0.
simulations and crystallised_dose_paths given summary method
Methods for simulation and calculating dose-paths added.
A bit more on the general selector interface.
Everything new has tests, and more tests on old stuff.
dfcrm, BOIN, 3+3 models supported.
several objects included to facilitate stopping at different events.
class for a fixed escalation plan included, as sometimes used with CRM.