Changelog

Source: NEWS.md

escalation 0.2.3

  • Added three new vignettes on phase I/II designs, TITE-designs, and combination designs.
  • Added BOIN-COMB MTD selector
  • Added tests and docs
  • Fixed bugs and typos

escalation 0.2.2

  • Added boin12_rds() to tabulate desirability scores in a BOIN12 trial.

escalation 0.2.1

  • Added unadmit_untested(), a selector to explicitly mark any untested and non-recomended dose as inadmissible via dose_admissible().

escalation 0.2.0

  • Added support for treatment combinations by allowing dose to become a vector of indices rather than a scalar.
  • Added BOIN COMB design for treatment combinations.

escalation 0.1.102024-06-27

  • Added TITE methods

escalation 0.1.92024-05-22

  • Fixed inheritance problems with as_tibble, summary and print dose_selector generics
  • Added many tests of dose_selector consistency.

escalation 0.1.82024-02-23

  • Made tests faster for CRAN

escalation 0.1.7

  • Added ability to import and export PatientSamples
  • Split the simulation vignette

escalation 0.1.6

  • Implement efficient simulation comparison method of Sweeting et al. in simulate_compare()
  • Implement BOIN12 design
  • Add MTD / OBD selectors for TPI, mTPI, mTPI2 and BOIN12 for final dose choice at end of a trial

escalation 0.1.52023-05-29

  • Add mTPI2 dose-finding method
  • Fixed some bugs

escalation 0.1.42020-10-18

  • Added Neuenschwander, Branson & Sponer’s method for phase I.
  • Added Ji et al.’s TPI & mTI methods for phase I.
  • Added Thall & Cook’s EffTox method for phase I/II.
  • Added Wages & Tait’s method for phase I/II.

escalation 0.1.32020-05-12

  • Mainly small changes to comply with dplyr v1.0.
  • simulations and crystallised_dose_paths given summary method
  • NOTE squash

escalation 0.1.22020-04-14

  • Methods for simulation and calculating dose-paths added.
  • A bit more on the general selector interface.
  • Everything new has tests, and more tests on old stuff.

escalation 0.1.12020-03-08

  • Initial release.
  • dfcrm, BOIN, 3+3 models supported.
  • several objects included to facilitate stopping at different events.
  • class for a fixed escalation plan included, as sometimes used with CRM.