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escalation
0.1.8
Reference
Articles
Using escalation
Continual Reassessment Method
Neuenschwander, Branson & Gsponer
Toxicity Probability Interval Design
Modified Toxicity Probability Interval Design
Bayesian Optimal Interval Design
Working with dose-paths
Simulating dose-escalation trials
Comparing dose-escalation designs by simulation
Changelog
Changelog
Source:
NEWS.md
escalation 0.1.6
Implement efficient simulation comparison method of Sweeting et al. in simulate_compare()
Implement BOIN12 design
Add MTD / OBD selectors for TPI, mTPI, mTPI2 and BOIN12 for final dose choice at end of a trial
escalation 0.1.5
2023-05-29
Add mTPI2 dose-finding method
Fixed some bugs
escalation 0.1.4
2020-10-18
Added Neuenschwander, Branson & Sponer’s method for phase I.
Added Ji et al.’s TPI & mTI methods for phase I.
Added Thall & Cook’s EffTox method for phase I/II.
Added Wages & Tait’s method for phase I/II.
escalation 0.1.3
2020-05-12
Mainly small changes to comply with dplyr v1.0.
simulations and crystallised_dose_paths given summary method
NOTE squash
escalation 0.1.2
2020-04-14
Methods for simulation and calculating dose-paths added.
A bit more on the general selector interface.
Everything new has tests, and more tests on old stuff.
escalation 0.1.1
2020-03-08
Initial release.
dfcrm, BOIN, 3+3 models supported.
several objects included to facilitate stopping at different events.
class for a fixed escalation plan included, as sometimes used with CRM.
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