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escalation
0.1.10
Reference
Articles
Using escalation
Continual Reassessment Method
Neuenschwander, Branson & Gsponer
Toxicity Probability Interval Design
Modified Toxicity Probability Interval Design
Bayesian Optimal Interval Design
Working with dose-paths
Simulating dose-escalation trials
Comparing dose-escalation designs by simulation
Changelog
Changelog
Source:
NEWS.md
escalation 0.1.10
Added TITE methods
escalation 0.1.9
2024-05-22
Fixed inheritance problems with as_tibble, summary and print dose_selector generics
Added many tests of dose_selector consistency.
escalation 0.1.8
2024-02-23
Made tests faster for CRAN
escalation 0.1.7
Added ability to import and export PatientSamples
Split the simulation vignette
escalation 0.1.6
Implement efficient simulation comparison method of Sweeting et al. in simulate_compare()
Implement BOIN12 design
Add MTD / OBD selectors for TPI, mTPI, mTPI2 and BOIN12 for final dose choice at end of a trial
escalation 0.1.5
2023-05-29
Add mTPI2 dose-finding method
Fixed some bugs
escalation 0.1.4
2020-10-18
Added Neuenschwander, Branson & Sponer’s method for phase I.
Added Ji et al.’s TPI & mTI methods for phase I.
Added Thall & Cook’s EffTox method for phase I/II.
Added Wages & Tait’s method for phase I/II.
escalation 0.1.3
2020-05-12
Mainly small changes to comply with dplyr v1.0.
simulations and crystallised_dose_paths given summary method
NOTE squash
escalation 0.1.2
2020-04-14
Methods for simulation and calculating dose-paths added.
A bit more on the general selector interface.
Everything new has tests, and more tests on old stuff.
escalation 0.1.1
2020-03-08
Initial release.
dfcrm, BOIN, 3+3 models supported.
several objects included to facilitate stopping at different events.
class for a fixed escalation plan included, as sometimes used with CRM.
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