• Implement efficient simulation comparison method of Sweeting et al. in simulate_compare()
  • Implement BOIN12 design
  • Add MTD / OBD selectors for TPI, mTPI, mTPI2 and BOIN12 for final dose choice at end of a trial
  • Add mTPI2 dose-finding method
  • Fixed some bugs
  • Added Neuenschwander, Branson & Sponer’s method for phase I.
  • Added Ji et al.’s TPI & mTI methods for phase I.
  • Added Thall & Cook’s EffTox method for phase I/II.
  • Added Wages & Tait’s method for phase I/II.
  • Mainly small changes to comply with dplyr v1.0.
  • simulations and crystallised_dose_paths given summary method
  • NOTE squash
  • Methods for simulation and calculating dose-paths added.
  • A bit more on the general selector interface.
  • Everything new has tests, and more tests on old stuff.
  • Initial release.
  • dfcrm, BOIN, 3+3 models supported.
  • several objects included to facilitate stopping at different events.
  • class for a fixed escalation plan included, as sometimes used with CRM.