Dose-paths with probabilities attached.

dose_paths reflect all possible paths a dose-finding trial may take. When the probability of those paths is calculated using an assumed set of true dose-event probabilities, in this package those paths are said to be crysallised. Once crystallised, operating charactersitics can be calculated.

crystallised_dose_paths(
  dose_paths,
  true_prob_tox,
  true_prob_eff = NULL,
  terminal_nodes
)

Arguments

dose_paths

Object of type dose_paths

true_prob_tox

vector of toxicity probabilities at doses 1..n

true_prob_eff

vector of efficacy probabilities at doses 1..n, optionally NULL if efficacy not evaluated.

terminal_nodes

tibble of terminal nodes on the dose-paths

Value

An object of type crystallised_dose_paths

Examples

# Calculate dose paths for the first three cohorts in a 3+3 trial of 5 doses:
paths <- get_three_plus_three(num_doses = 5) %>%
  get_dose_paths(cohort_sizes = c(3, 3, 3))

# Set the true probabilities of toxicity
true_prob_tox <- c(0.12, 0.27, 0.44, 0.53, 0.57)
# Crytallise the paths with the probabilities of toxicity
x <- paths %>% calculate_probabilities(true_prob_tox)
# And then examine, for example, the probabilities of recommending each dose
# at the terminal nodes of these paths:
prob_recommend(x)
#>     NoDose          1          2          3          4          5 
#> 0.12854451 0.33600635 0.19081343 0.29807918 0.04655654 0.00000000