This method optionally prevents dose selectors from skipping doses when escalating and / or deescalating. The default is that skipping when escalating is prevented but skipping when deescalating is permitted, but both of these behaviours can be altered.

dont_skip_doses(
  parent_selector_factory,
  when_escalating = TRUE,
  when_deescalating = FALSE
)

Arguments

parent_selector_factory

Object of type selector_factory.

when_escalating

TRUE to prevent skipping when attempting to escalate.

when_deescalating

TRUE to prevent skipping when attempting to deescalate.

Value

an object of type selector_factory that can fit a dose-finding model to outcomes.

Examples

skeleton <- c(0.05, 0.1, 0.25, 0.4, 0.6) target <- 0.25 model1 <- get_dfcrm(skeleton = skeleton, target = target) %>% dont_skip_doses() fit1 <- model1 %>% fit('1NNN') model2 <- get_dfcrm(skeleton = skeleton, target = target) fit2 <- model2 %>% fit('1NNN') # fit1 will not skip doses fit1 %>% recommended_dose()
#> [1] 2
# But fit2 will: fit2 %>% recommended_dose()
#> [1] 4
# Similar demonstration for de-escalation model1 <- get_dfcrm(skeleton = skeleton, target = target) %>% dont_skip_doses(when_deescalating = TRUE) fit1 <- model1 %>% fit('1NNN 2N 3TTT') model2 <- get_dfcrm(skeleton = skeleton, target = target) fit2 <- model2 %>% fit('1NNN 2N 3TTT') # fit1 will not skip doses fit1 %>% recommended_dose()
#> [1] 2
# But fit2 will: fit2 %>% recommended_dose()
#> [1] 1