Enforce that a trial path has followed the 3+3 method.

This function stops with en error if it detects that outcomes describing a trial path have diverged from that advocated by the 3+3 method.

Usage

enforce_three_plus_three(outcomes, allow_deescalate = FALSE)

Arguments

outcomes

Outcomes observed. See parse_phase1_outcomes.

allow_deescalate

TRUE to allow de-escalation, as described by Korn et al. Default is FALSE.

Value

Nothing. Function stops if problem detected.

Examples

if (FALSE) { # \dontrun{
enforce_three_plus_three('1NNN 2NTN 2NNN')  # OK
enforce_three_plus_three('1NNN 2NTN 2N')  # OK too, albeit in-progress cohort
enforce_three_plus_three('1NNN 1N')  # Not OK because should have escalated
} # }