Fit the 3+3 model to some outcomes.

three_plus_three(
  outcomes,
  num_doses,
  allow_deescalate = FALSE,
  strict_mode = TRUE
)

Arguments

outcomes: Outcomes observed. See parse_phase1_outcomes.
num_doses: Number of doses under investigation.
allow_deescalate: TRUE to allow de-escalation, as described by Korn et al. Default is FALSE.
strict_mode: TRUE to raise errors if it is detected that the 3+3 algorithm has not been followed.

Value

lits containing recommended_dose and a logical value continue saying whether the trial should continue.

References

Storer BE. Design and Analysis of Phase I Clinical Trials. Biometrics. 1989;45(3):925-937. doi:10.2307/2531693

Korn EL, Midthune D, Chen TT, Rubinstein LV, Christian MC, Simon RM. A comparison of two phase I trial designs. Statistics in Medicine. 1994;13(18):1799-1806. doi:10.1002/sim.4780131802

Examples


three_plus_three('2NNN 3NNT', num_doses = 7)
#> $recommended_dose
#> [1] 3
#> 
#> $continue
#> [1] TRUE
#> 
#> attr(,"class")
#> [1] "three_plus_three_fit"